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Rapid Direct Diagnosis of Deletions Carriers of Duchenne and Becker Muscular Dystrophies Lancet 344:302-303, Fassati,A.,et al, 1994 See this aricle in Pubmed Article Abstract Thirteen families and 34 women at risk for being carriers of Duchenne and Becker muscular dystrophies were analyzed blind by restriction fragment length polymorphisms(RFLPs)and a new,non-radioactive direct test based on competitive polymerase-chain-reaction(PCR)amplification.All obligate carriers were correctly diagnosed by RFLPs and competitive PCR,and 7 women with a 99%risk of being carriers were also diagnosed carriers by competitive PCR.There were no false positives or false negatives.Only 1 PCR result was noninformative.Our test allows rapid,precise,and direct carrier diagnosis of women whose relatives have a known deletion of the dystrophy gene.

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(click to filter results - removes previous filter) dystrophin muscular dystrophy muscular dystrophy,Becker muscular dystrophy,Becker,carrier muscular dystrophy,Duchenne,carrier neurologic disease,diagnoses of polymerase chain reaction RFLPs

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